The DAG1 Antibody (C-term) from MyBioSource.com is a Rabbit Polyclonal antibody to alpha-dystroglycan, beta Dystroglycan, DAG, DAG1, DG, and dystroglycan. This antibody recognizes Human, Mouse, and Rabbit antigen. The DAG1 Antibody (C-term) has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Dystroglycan is a laminin binding component of the
dystrophin-glycoprotein complex which provides a linkage between
the subsarcolemmal cytoskeleton and the extracellular matrix.
Dystroglycan 1 is a candidate gene for the site of the mutation in
autosomal recessive muscular dystrophies. The dramatic reduction of
dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of
linkage between the sarcolemma and extracellular matrix, rendering
muscle fibers more susceptible to necrosis. Dystroglycan also
functions as dual receptor for agrin and laminin-2 in the Schwann
cell membrane. The muscle and nonmuscle isoforms of dystroglycan
differ by carbohydrate moieties but not protein sequence.
Alternative splicing results in multiple transcript variants all
encoding the same protein